The study will offer an innovative new proof to ensure the effect of needle knife treatment plus sodium hyaluronate injection on KOA, which can further guide the choice of treatment. Butylphthalide is trusted when it comes to adjunctive remedy for vascular alzhiemer’s disease; nonetheless, the clinical evidences aren’t really synthesized yet. We proposed a systematic analysis and meta-analysis to judge the effectiveness tumor biology and security of butylphthalide as adjunctive treatment for vascular dementia. Seven electronic databases (China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, Asia Biomedical Literature Database, Pubmed, EMBASE and Cochrane collection) are going to be searched for eligible randomized controlled trials (RCTs). Needed information of included researches will soon be gathered. High quality of researches would be evaluated using Cochrane danger of bias assessment tool. Information synthesis would be carried out utilizing Assessment management software. Subgroup evaluation and sensitivity analysis will also be held. Acute mountain sickness (AMS) may be the result when individuals accessing high altitude in a brief period of the time. As a cyclooxygenase (COX) inhibitor, ibuprofen could relieve the symptoms of AMS. Nevertheless, whether it can prevent AMS or not is still questionable. It is necessary to do a meta-analysis to gauge the role of ibuprofen in AMS prophylaxis. PubMed, EMBASE, Medline, ISI Web of Science, Cochrane Library, Asia National Knowledge Infrastructure (CNKI) will undoubtedly be searched for the relevant published studies that explored the value of ibuprofen in AMS prophylaxis from inception to October 2020. The data would be UNC1999 datasheet separately removed by 2 scientists. Danger of prejudice will be examined predicated on Cochrane risk of bias assessment tool. Heterogeneity one of the included scientific studies will undoubtedly be evaluated by χ and I values. The meta-analysis had been carried out by RevMan pc software variation 5.3. Uremic pruritus (UP) is a very common and tormenting symptom in end-stage renal illness patients undergoing upkeep hemodialysis. An escalating number of studies have already been posted in the past few years to guide the potency of montelukast for UP. We shall perform a thorough systematic analysis and meta-analysis to evaluate Cytogenetic damage effectiveness of montelukast for UP in hemodialysis clients. The following electronic databases were searched Pubmed, Embase, Web of Science, Cochrane Library, the Asia National Knowledge Infrastructure, Chinese Biomedical Literature Database, and China Science and tech Journal Database. The range of book time had been from the inception of this database to December 2020. Two reviewers will individually perform article selection, information collection, and assessment of danger of prejudice. Any disagreement are going to be fixed by conversation with the 3rd reviewer. Meta-analysis would be performed by Assessment management 5.3. The Cochrane Collaboration device would be utilized to evaluate the risk of bias. This study will provide an organized synthesis of existing published data to explore the effectiveness of montelukast for UP in hemodialysis clients. This systematic review and meta-analysis will provide clinical evidence for the effectiveness of montelukast for UP in hemodialysis patients and inform our understanding of the value of montelukast in increasing pruritus symptoms. This study will help physicians, clients, and plan makers which will make better choices regarding the proper role of montelukast as an element of patient management routines. The increasing prevalence of obesity worldwide necessitates the provision of assistance for all customers. Patients with obesity appreciate receiving guidance from physicians. Earlier research reports have qualitatively explored clinicians’ guidance for losing weight; but, that is limited by primary doctors or basic practitioners doing work in neighborhood wellness facilities. In contrast, Korean Medicine Doctors (KMDs) have actually addressed patients with obesity making use of a holistic approach with a multicomponent strategy on counseling. Nonetheless, there is certainly currently no information regarding KMDs’ consulting practices for losing weight. Therefore, the present research will explore KMDs’ experience in guidance for losing weight and explain the constituents of counseling for losing weight in Korean medication rehearse. This qualitative study uses a phenomenological framework. The KMDs who’ve worked >1 year as practitioners in dealing with patients with obesity may be invited to spell it out their lived experiences of counseling patients for losing weight. Purposive and snowball sampling would be undertaken to make sure that the sample provides information-rich situations which can be representative of KMDs’ experiences of guidance for losing weight.